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Symptoms of tetrasomy X are highly variable, ranging from relatively mild to severe. Speech, occupational, and physical therapy may also be needed depending on the severity of the symptoms. This article includes a list of references , but its sources remain unclear because it has insufficient inline citations. Tetrasomy X was first described in , and since then approximately cases have been reported worldwide. Medical literature reports four tetra-X pregnancies, two healthy, one with trisomy 21 , one stillborn with omphalocele. The majority have also been reported as being longer and taller. An informal study of twenty girls with tetrasomy and pentasomy X found that 10 percent of patients had joint laxity in the hips, while 20 percent had joint limitations.

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