Research suggests, however, that in a few births per thousand some individuals will be born with a single sex chromosome 45X or 45Y sex monosomies and some with three or more sex chromosomes 47XXX, 47XYY or 47XXY, etc. In some instances of Turner syndrome, there is slight mental retardation. In , chromosomal analysis of two human disorders, Turner syndrome and Klinefelter syndrome, demonstrated for the first time that genetic factors on the Y chromosomes of mammals are important determinants in male sex. Men inheriting an additional Y chromosome are usually taller than average and are prone to acne because they produce higher than average levels of testosterone. Indeed, most cases of SCA are compatible with normal life expectancy and often go undiagnosed. It is apparent, then, that different cultures have taken different approaches to creating gender distinctions, with more or less recognition of fluidity and complexity of gender. Gender, typically described in terms of masculinity and femininity, is a social construction that varies across different cultures and over time.
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