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Once proper SOX9 levels are reached, the bipotential cells of the gonad begin to differentiate into Sertoli cells. Further information: Sex verification in sports. For other uses, see SRY disambiguation. Protein-coding gene in the species Homo sapiens. Asian Journal of Andrology. Within related mammalian groups there are homologies within the first base pairs upstream from the translational start site. Therefore, SRY plays an important role in sex determination. The central region encompasses the HMG high-mobility group domain, which contains nuclear localization sequences and acts as the DNA-binding domain. More reference expression data.

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